Skip to main content
SpringerLink
Log in

Adipose-derived Stem Cells and their Secretory Factors for Skin Aging

  • Reference work entry
Textbook of Aging Skin

  • 599 Accesses

Abstract

The term “stem cell” has attracted increasing attention of the scientific community as well as of the general public. In many aspects, however, it is still confusing and difficult to understand and interpret information about stem cells. They are vital to humans for numerous reasons. Groups of stem cells in some adult tissues give rise to replacement cells for the tissues that are destroyed through injury, disease, or aging [1]. Knowledge relating to how healthy cells replace diseased or otherwise damaged cells, would allow development of medical therapies focusing on creation of compatible cell lines to replace aged or diseased cells in the body. The concept of regenerative medicine using the body’s own stem cells and growth factors to repair tissue may be realizable as science and clinical experience converge to develop alternative therapeutic strategies to treat the damaged or diseased tissue. Stem cell-based therapies are also being tried in tissue engineering: The aim of tissue engineering is to repair and regenerate damaged organs or tissues using a combination of cells, biomaterials, and cytokines [1–4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 499.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Barry FP, et al. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004;36:568–584.

    CAS  PubMed  Google Scholar 

  2. Gimble J, et al. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 2003;5:362–369.

    PubMed  Google Scholar 

  3. Kinnaird T, et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res. 2004;94:678–685.

    CAS  PubMed  Google Scholar 

  4. Zuk PA, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279–4295.

    CAS  PubMed  Google Scholar 

  5. Kim WS, et al. Antiwrinkle effect of adiposederived stell cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53:96–102.

    CAS  PubMed  Google Scholar 

  6. Kim WS, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007;48:15–24.

    CAS  PubMed  Google Scholar 

  7. Park BS, et al. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008;34:1323–1326.

    CAS  PubMed  Google Scholar 

  8. Kim WS, et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci. 2008;49:133–142.

    CAS  PubMed  Google Scholar 

  9. Kim WS, et al. Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1. Biol Pharm Bull. 2008;31:606–610.

    CAS  PubMed  Google Scholar 

  10. Izadpanah R, et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem. 2006;99:1285–1297.

    CAS  PubMed  Google Scholar 

  11. Porada CD, et al. Adult mesenchymal stem cells: a pluripotent population with multiple applications. Curr Stem Cell Res Ther. 2006;1:365–369.

    CAS  PubMed  Google Scholar 

  12. Boquest AC, et al. Epigenetic programming of mesenchymal stem cells from human adipose tissue. Stem Cell Rev. 2006;2:319–329.

    CAS  PubMed  Google Scholar 

  13. Huang T, et al. Neuron-like differentiation of adipose derived stem cells from infant piglets in vitro. J Spinal Cord Med. 2007;30:35–40.

    Google Scholar 

  14. Kern S, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24:1294–1301.

    CAS  PubMed  Google Scholar 

  15. Katz AJ, et al. Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells. 2005;23:412–423.

    CAS  PubMed  Google Scholar 

  16. Anghileri E, et al. Neuronal differentiation potential of human adipose-derived mesenchymal stem cells. Stem Cells Dev. 2008;17:909–916.

    CAS  PubMed  Google Scholar 

  17. Bunnell BA, et al. Differentiation of adipose stem cells. Methods Mol Biol. 2008;456:155–171.

    PubMed  Google Scholar 

  18. Gimble JM, et al. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007;100:1249–1260.

    CAS  PubMed  Google Scholar 

  19. Schipper BM, et al. Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg. 2008;60:538–544.

    CAS  PubMed  Google Scholar 

  20. Jurgens WJ, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: Implications for cell-based therapies. Cell Tissue Res. 2008;332:415–426.

    PubMed  Google Scholar 

  21. Oedayrajsingh-Varma MJ, et al. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy. 2006;8:166–177.

    CAS  PubMed  Google Scholar 

  22. Schachinger V, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–1221.

    CAS  PubMed  Google Scholar 

  23. Schachinger V, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J. 2006;27:2775–2783.

    PubMed  Google Scholar 

  24. Uemura R, et al. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006;98:1414–1421.

    CAS  PubMed  Google Scholar 

  25. Wang M, et al. Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. Shock. 2006;25:454–459.

    PubMed  Google Scholar 

  26. Crisostomo PR, et al. In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power. Surgery. 2007;142:215–221.

    PubMed  Google Scholar 

  27. Patel KM, et al. Mesenchymal stem cells attenuate hypoxic pulmonary vasoconstriction by a paracrine mechanism. J Surg Res. 2007;143:281–285.

    CAS  PubMed  Google Scholar 

  28. Roche S, et al. Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signature. Proteomics. 2009;9:223–232.

    CAS  PubMed  Google Scholar 

  29. Zvonic S, et al. Secretome of primary cultures of human adipose-derived stem cells. Mol Cell Proteomics. 2007;6:18–28.

    CAS  PubMed  Google Scholar 

  30. Wu Y, et al. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem cells. 2007;25:2648–2659.

    CAS  PubMed  Google Scholar 

  31. Sasaki M, et al. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol. 2008;180:2581–2587.

    CAS  PubMed  Google Scholar 

  32. Chen L, et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE. 2008;3:e1886.

    PubMed  Google Scholar 

  33. Baregamian N, et al. IGF-1 protects intestinal epithelial cells from oxidative stressinduced apoptosis. Surg Res. 2006;136:31–37.

    CAS  Google Scholar 

  34. Rahman ZA, et al. Antioxidant effects of glutathione and IGF in a hyperglycaemic cell culture model of fibroblasts: some actions of advanced glycaemic end products (AGE) and nicotine. Endocr Metab Immune Disord Drug Targets. 2006;6:279–286.

    CAS  PubMed  Google Scholar 

  35. Shibuki H, et al. Expression and neuroprotective effect of hepatocyte growth factor in retinal ischemia-reperfusion injury. Invest Ophthalmol Visual Sci. 2002;43:528–536.

    Google Scholar 

  36. Tsao YP, et al. Pigment epithelium derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells. Life Sci. 2006;79:545–550.

    CAS  PubMed  Google Scholar 

  37. Kida H, et al. Protective effect of IL-6 on alveolar epithelial cell death induced by hydrogen peroxide. Am J Physiol. 2005;288:342–349.

    Google Scholar 

  38. Liochev SI, et al. How does superoxide dismutase protect against tumor necrosis factor: a hypothesis informed by effect of superoxide on “free” iron. Free Radic Biol Med. 1997;23:668–671.

    CAS  PubMed  Google Scholar 

  39. Kang SH, et al. Improvement of melasma and scars with the secretory factors from ADSCs. Korean J Dermatol. 2007;45(Suppl. 2):136.

    Google Scholar 

  40. Kang WH, et al. Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol. 2002;146:228–237.

    CAS  PubMed  Google Scholar 

  41. Kim EH, et al. The vascular charateristics of melasma. J Dermatol Sci. 2007;46:111–116.

    CAS  PubMed  Google Scholar 

  42. Park BS, et al. Rejuvenation of aging skin using fractional CO2 laser resurfacing followed by topical application of ADSC protein extract. Kor J Dermatol. 2008;46(Suppl 1):266–267.

    Google Scholar 

  43. Matsumoto D, et al. Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng. 2006;12:3375–3382.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leaders Cosmetic Dermatology and Skin Enhancement Center, 60-6 Nonhyun-dong, Gangnam-gu, 135-816, Seoul, Korea

    Byung-Soon Park

  2. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea

    Byung-Soon Park

  3. Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

    Won-Serk Kim

Authors
  1. Byung-Soon Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Won-Serk Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Park, BS., Kim, WS. (2010). Adipose-derived Stem Cells and their Secretory Factors for Skin Aging. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-89656-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation