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Textbook of Aging Skin pp 121–128Cite as

Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases and Serine Proteinases in Skin Aging Process

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Abstract

Skin aging can be classified into two types: intrinsic aging and photoaging [1]. Intrinsic aging is the basic biological process common to all living things and is characterized as an age-dependent deterioration of skin functions and structures, such as epidermal atrophy and epidermal–dermal junctional flattening [2]. Photoaging is well known to be a consequence of chronic exposure of the skin to sunlight. Sun-exposed skin, such as face or neck skin, clearly appears to be “prematurely aged” in comparison with the relatively sun-protected skin of the trunk or thigh, and is characterized by various clinical features, including wrinkles, sagging, roughness, sallowness, pigmentary changes, telangiectasis, and neoplasia [3, 4]. The histological features of sun-exposed skin include cellular atypia, loss of polarity, flattening of the dermal–epidermal junctions (DEJ), a decrease in collagen, and dermal elastosis [2, 5].

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Author information

Authors and Affiliations

  1. Shiseido Research Center, 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama, 224-8558, Japan

    Satoshi Amano

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  1. Satoshi Amano
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Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

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Amano, S. (2010). Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases and Serine Proteinases in Skin Aging Process. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_12

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  • DOI: https://doi.org/10.1007/978-3-540-89656-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

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