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Molecular Genetic Pathology pp 483–497Cite as

Human Tissue Biorepository

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Abstract

The provision of human tissues to support biomedical research faces many challenges, including some misconceptions by investigators of some of the issues involved in obtaining human tissues for research. This chapter is to aid investigators in understanding some of the limitations faced by biorepositories in the provision of human tissues to support research. This chapter also will be useful to sites that are considering establishing a human tissue biorepository. Challenges currently facing human tissue biorepositories include a general decrease in the sizes of many tumors and a great decrease in the availability of metastatic lesions with both these challenges due to improved approaches to the imaging of tumors as well as metastases. The availability of appropriate tissues to study neoplastic lesions also has been greatly reduced for some cancers such as breast by the increasing use of neoadjuvant therapy which may decrease the size of primary and metastatic lesions, differentially affect cellular populations in cancers, and prevent their accurate staging. Another challenge is the increasing use of fine needle aspirations in tissue diagnoses. The availability of adequate resources to support tissue biorepositories has always been a challenge which is complicated by ill-advised, unnecessary proposed changes in governmental regulations acting as unfunded mandates affecting biorepository operations. Biorepositories are attempting to meet these challenges by introducing new methods of sampling tissues such as nitrocellulose blotting and by adapting methods so that paraffin embedded tissues can be used; also, additional tissues specifically to support research can be obtained directly from consented patients.

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Further Reading

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Acknowledgments

Supported by the Cooperative Human Tissue Network (5U01CA44968), UAB SPORES in Breast Cancer (5P50CA0189019), Pancreatic Cancer (2P50CA101955) and Cervical Cancer (5P50CA098252), Comprehensive Cancer Center Core Support Grant (P30CA13148).

Author information

Authors and Affiliations

  1. Department of Pathology, The University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA

    William E. Grizzle MD, PhD (Professor of Pathology, Head, Program for Translational Research in Neoplasia, Director, Tissue Procurement and Banking Facility, Senior Scientist, UAB Comprehensive Cancer Center; Center for Aging; Metabolic Bone Disease Research Center, Senior Editor, Clinical Cancer Research) & Walter C. Bell MD (Associate Professor)

  2. Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, USA

    Katherine C. Sexton MBA (Assistant Director, University of Alabama at Birmingham, Tissue Collection and Banking Facility)

Authors
  1. William E. Grizzle MD, PhD
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  2. Katherine C. Sexton MBA
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  3. Walter C. Bell MD
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Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Pathology, Indiana University, N. University Blvd. 550, Indianapolis, 46202, Indiana, USA

    Liang Cheng

  2. Dept. Pathology, Mount Sinai School of Medicine, Gustave L. Levy Place 1, New York, 10029, New York, USA

    David Y. Zhang

  3. School of Medicine, Department of Pathology and, Indiana University, 635 Barnhill Drive, Indianapolis, 46202, Indiana, USA

    John N. Eble

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© 2013 Springer Science+Business Media New York

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Grizzle, W.E., Sexton, K.C., Bell, W.C. (2013). Human Tissue Biorepository. In: Cheng, L., Zhang, D., Eble, J. (eds) Molecular Genetic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4800-6_17

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  • DOI: https://doi.org/10.1007/978-1-4614-4800-6_17

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4799-3

  • Online ISBN: 978-1-4614-4800-6

  • eBook Packages: MedicineReference Module Medicine

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