2013, pp 2191-2212

Toponomics

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Definition

Toponomics is a discipline in systems biology, molecular cell biology, and histology concerning the study of the toponome of organisms. The toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues. The term “toponome” is derived from the ancient Greek nouns “topos” (τóπoς; place, position) and “nomos” (νóμoς; law), addressing the fact that the network of biomolecules in cells follows topological rules enabling coordinated actions (Schubert 2003). This spatial organization can be described by a three symbol code (Schubert 2003, 2007a; Schubert et al. 2006). The core technology decoding the toponome is the dimension-unlimited functional super-resolution microscopy TIS.

Introduction

Cellular functionalities comprise at least four organizational levels: genome, transcriptome, proteome, and toponome. The toponome (Schubert 2003) is defined as the spatial network code of proteins and other biomolecules i ...