Reference Work Entry

Encyclopedia of Systems Biology

pp 1725-1728

Post-Transcriptional Gene Networks

  • Luiz O. F. PenalvaAffiliated withDepartment of Cellular and Structural Biology, Greehey Children’s Cancer Research Institute, University of Texas Health Science Center Email author 
  • , Dat T. VoAffiliated withDepartment of Cellular and Structural Biology, Greehey Children’s Cancer Research Institute, University of Texas Health Science Center
  • , Daniel R. BoutzAffiliated withInstitute for Cellular and Molecular Biology, University of Texas
  • , Andrew D. SmithAffiliated withMolecular and Computational Biology Section, Division of Biological Sciences, University of Southern California

Synonyms

Post-transcriptional operon; Post-transcriptional regulatory networks; Post-transcriptional regulons; Ribonome

Definition

Post-transcriptional gene regulatory networks are defined by a specific gene subset sharing commonalities in biological functions, ontology, or pathway that are co-regulated by either a specific RNA binding protein (RBP) or miRNA. MiRNAs and RBPs can regulate simultaneously the expression of hundreds of genes by recognizing specific sequence motifs located in untranslated regions (UTRs) in mRNA and in exons and introns in pre-mRNAs.

Characteristics

RBPs and their Role in Post-Transcriptional Regulation

Eukaryotes must coordinate the expression of multiple genes to accomplish diverse biological functions that are necessary for processes that include cell division, growth, and differentiation, among others. A major part of this coordinated expression occurs at the post-transcriptional level and is mainly controlled by RBPs. Among pr ...

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