Expression and Functional Activities of Glucose Transporters in the Central Nervous System
- G. G. Piroli
- , C. A. Grillo
- , L. R. Reznikov
- , L. P. Reagan
The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of glucose into cells throughout the periphery and the brain. The expression, regulation and activity of glucose transporters play an essential role in neuronal homeostasis, since glucose represents the primary energy source for the brain. Brain GLUTs exhibit both cell type and region specific localizations suggesting that the transport and utilization of glucose in the CNS is tightly regulated and compartmentalized. Brain GLUTs also exhibit discrete localizations, as well as unique subcellular localizations, indicating that GLUTs may be involved in highly specialized activities in the CNS such as glucose sensing. Insulin sensitive GLUTs are expressed in the brain suggesting that GLUTs may participate in the central actions of insulin, including cognitive function and homeostatic control of food intake. These results illustrate that the expression, regulation and trafficking of brain GLUTs are critically involved in maintaining neuronal homeostasis and responsiveness.
Reference Work Entry Metrics
- Expression and Functional Activities of Glucose Transporters in the Central Nervous System
- Reference Work Title
- Handbook of Neurochemistry and Molecular Neurobiology
- Reference Work Subtitle
- Neural Membranes and Transport
- pp 387-404
- Print ISBN
- Online ISBN
- Springer US
- Copyright Holder
- Springer Science+Business Media, LLC.
- Additional Links
- Editor Affiliations
- 1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research
- 2. Department of Psychiatry Millhauser Labs, Room MHL‐HN–604A, New York University School of Medicine
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