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Handbook of Neurochemistry and Molecular Neurobiology pp 1–12Cite as

Brain Tumor Angiogenesis

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Abstract:

The growth of malignant tumors of the central nervous system requires adequate supplies of oxygen and nutrients obtained by the formation of new capilliaries from existing blood vessels. This process is called angiogenesis. Accordingly, anti-angiogenic therapy represents a promising modality for the treatment of brain tumors. This review describes the main biological events, molecular factors and critical signaling cascades implicated in brain tumor angiogenesis. We also summarized the key attributes of the emerging synthetic small molecular inhibitors and molecular targets with anti-angiogenic activities that make them potent anti-tumor agents. The studies reviewed here suggest that there is an urgent need for a new comprehensive treatment strategy combining anti-angiogenic agents with conventional cytoreductive treatments in the control of brain cancer.

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Abbreviations

bFGF:

basic fibroblast growth factor

EGF:

epidermal growth factor

EGFR:

Epidermal growth factor receptor

FGF:

Fibroblast growth factors

FKBP :

FK506-binding protein

FTS:

farnesylthiosalicylic acid

HGA:

High-grade astrocytoma

HIF:

hypoxia-inducible transcription factor

HIF-1:

Hypoxia-inducible factor 1

HIF-1alpha:

Hypoxia-inducible factor 1alpha

IM:

intramuscular

MMPs:

matrix metalloproteinases

NABTC:

North American Brain Tumor Consortium

PDGF:

platelet derived growth factor

PDGF-R:

Platelet derived growth factor receptor

PDGFR-beta:

platelet-derived growth factor receptor-beta

PI3K:

phosphatidyl inositol-3 kinase

PIGF:

placental growth factor

PIP2:

Phosphatidyl inositol bi phosphate

PIP3:

phosphatidyl inositol tri phosphate

TNF-alpha:

tumor necrosis factor alpha

TSP:

Thrombospondin

PTEN:

Phosphatese and tensin hemalog

VEGF:

vascular endothelial growth factor

vHL:

von Hippel–Lindau

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  2. J. S. Rao
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Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Department of Neurosciences Division of Neurology, Medical University of South Carolina, 29425, 96 Jonathan Lucas Street, Suite 309, Charleston, SC, USA

    Naren Banik

  3. Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, 6439 Garners Ferry Road Building 2, Room C11, Columbia, SC, USA

    Swapan K. Ray

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© 2009 Springer Science+Business Media, LLC

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Lakka, S., Rao, J.S. (2009). Brain Tumor Angiogenesis. In: Lajtha, A., Banik, N., Ray, S.K. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30375-8_1

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