Abstract:
Sensory neuropathies comprise a heterogeneous group of diseases which are caused by damage of the sensory nerves and lead to sensory disturbances mainly affecting the feet and legs, and less frequently the hands and arms. This article defines sensory neuropathies and introduces clinical features and the underlying etiology as well as risk factors and possible complications. Physical as well as laboratory findings are presented and the diagnostic role of nerve conduction studies, nerve biopsy and skin biopsy studies are shortly discussed. Important clinical entities like diabetic or hereditary neuropathies amongst others are described in more detail. Finally, an overview addressing patient management and particularly, management of foot complications is given.
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Abbreviations
- HSAN:
-
Hereditary sensory and autonomic neuropathies
- HSN:
-
Hereditary sensory neuropathies
- NCS:
-
Nerve conduction studies
- QST:
-
Quantitative somatosensory testing
References
Auer-Grumbach M, Mauko B, Auer-Grumbach P, Pieber TR. 2006. Molecular genetics in sensory neuropathies. Neuromolecular Med 8: 147–158.
Cherry CL, Wesselingh SL, Lal L, McArthur JC. 2005. Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology 65: 1778–1781.
Cornblath LG, Johansson O, McArthur JC, Mellgren SI, Nolano M, et al. 2005. European federation of neurological societies. EFNS guidelines on the use of skin biopsies in the diagnosis of peripheral neuropathy. Eur J Neurol 10: 747–758.
Dawkins JL, Hulme DJ, Brahmbhatt SB, Auer-Grumbach M, Nicholson GA. 2001. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I. Nat Genet 27: 309–312.
Dworkin RH, Backonja M, Rowbotham MC 2003. Advances in neuropathic pain. Arch Neurol 60: 1524–1534.
Dyck PJ. 1993. Neuronal atrophy and degeneration predominantly affecting peripheral sensory and autonomic neurons. Peripheral Neuropathy. 3rd ed. Dyck PJ, Thomas PK, Griffin JW, Low PA, Poduslo JF, editors. Philadelphia: W.B. Saunders; pp. 1065–1093.
Fink E, Oaklander AL. 2006. Small-fiber neuropathy: Answering the burning questions. Sci Aging Knowl Environ 6: pe7.
Gidal BE. 2006. New and emerging treatment options for neuropathic pain. Am J Manag Care 12: 269–278.
Gilron I, Flatters SJ. 2006. Gabapentin and pregabalin for the treatment of neuropathic pain: A review of laboratory and clinical evidence. Pain Res Manag Summer 11 (Suppl. A): 16A–29A.
Lafreniere RG, Mac Donald ML, Dube MP, Mac Farlane J, O'Driscoll M, et al. 2004. Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the study of Canadian genetic isolates. Am J Hum Genet 74: 1064–1073.
Mueller MJ, Hastings M, Commean PK, Smith KE, Pilgram TK, et al. 2003. Forefoot structural predictors of plantar pressures during walking in people with diabetes and peripheral neuropathy. J Biomech 36: 1009–1017.
Pascuzzi RM. 2003. Peripheral neuropathies in clinical practice. Med Clin North Am 87: 697–724.
Ramsey SD, Nemton K, Blough D, et al. 1999. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes care 22: 382–387.
Thomas PK, Tomlinson DR. 1999. Diabetic and hypoglycemic neuropathy. Diabetic Neuropathy. Dyck PJ, Thomas PK, editors. 2nd ed, Elsevier, pp. 1219–1250.
Verhoeven K, De Jonghe P, Coen K, Verpoorten N, Auer-Grumbach M, et al. 2003. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am J Hum Genet 72: 722–727.
Verhoeven K, Timmerman V, Mauko B, Pieber TR, De Jonghe P, et al. 2006. Recent advances in hereditary sensory and autonomic neuropathies. Curr Opin Neurol 124: 271–276.
Wellmer A, Misra VP, Sharief MK, Kopelman PG, Anand P. 2001. A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy. J Peripher Nerv Syst 6: 204–210.
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Auer-Grumbach, M., Auer-Grumbach, P., Pieber, T. (2007). Sensory Neuropathies. In: Lajtha, A., Johnson, D.A. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-30374-1_9
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DOI: https://doi.org/10.1007/978-0-387-30374-1_9
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