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Drug Discovery and Evaluation pp 195–209Cite as

Peripheral Nervous System

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1 I.H.1. Tolerance of Local Anesthetics

1.1 I.H.1.1. General Considerations

One generally has to distinguish between surface anesthesia, infiltration anesthesia and conduction anesthesia (Fromherz 1922; Schaumann 1938; Camougis & Takman 1971). Special local tolerance tests have been developed for each of these applications including peridural and intrathecal injections.

1.1.1 References

Camougis G, Takman BH (1971) Nerve and nerve-muscle preparations (as applied to local anesthetics) In: Schwartz A (ed) Methods in Pharmacology, Vol 1, Appleton-Century-Crofts, Educational Division. Meredith Corp, New York, pp 1–40

Fromherz K (1922) Über die Wirkung verschiedener Gruppen der Lokalanästhetika im Lichte verschiedener Untersuchungsmethoden. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 93:72–91

Schaumann O (1938) Chemie und Pharmakologie der Lokalanaesthetica. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 190:30–51

1.2 I.H.1.2. Irritancy after Surface Anesthesia

1.2.1 Purpose and Rationale

S...

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    H. Gerhard Vogel

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Vogel, H.G. (2006). Peripheral Nervous System. In: Vogel, H.G., Hock, F.J., Maas, J., Mayer, D. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29804-5_8

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