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Drug Discovery and Evaluation pp 385–393Cite as

Magnetic Resonance Imaging in Pharmaceutical Safety Assessment

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1 I.Q.1. Introduction

ICIpharmaceutical safety assessment (now AstraZeneca) and Sandoz (now Novartis) introduced the first Magnetic Resonance Imaging (MRI) scanners into the pharmaceutical industry over twenty years ago. Most major pharmaceutical companies have since invested in in-house MRI for the evaluation of preclinical drug efficacy and most are now using MRI in clinical trials at extramural centres. MRI has been successful in the pharmaceutical industry for the same reasons that it is popular in clinical practice; it is a non-invasive imaging technique with superb soft tissue contrast capable of delivering quantitative 3D information on organ anatomy and function (Beckmann et al. 2004; Maronpot et al. 2004). Because it is non-invasive aside from the need to anaesthetise animals to immobilise them during image acquisition, animals can be imaged on multiple occasions and studies can be designed so that each animal serves as its own control increasing the statistical power of...

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Author information

Authors and Affiliations

  1. DECS Imaging, AstraZeneca, 43183, Mölndal, Sweden

    Paul Hockings

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  1. Paul Hockings
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Correspondence to Paul Hockings .

Editor information

Editors and Affiliations

  1. Johann-Wolfgang-Goethe-Universität, Frankfurt am Main, Germany

    H. Gerhard Vogel Prof.

  2. Altstadt 19, 64807, Dieburg, Germany

    Franz Jakob Hock Dr. (Editor) (Editor)

  3. Aventis Pharma Deutschland GmbH, Industriepark Hoechst, 65926, Frankfurt, Germany

    Jochen Maas Dr. (Co-Editor) (Co-Editor)

  4. Alte Poststraße 10, 65510, Idstein, Germany

    Dieter Mayer Prof. (Co-Editor) (Co-Editor)

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© 2006 Springer-Verlag Berlin Heidelberg New York

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Hockings, P. (2006). Magnetic Resonance Imaging in Pharmaceutical Safety Assessment. In: Vogel, H.G., Hock, F.J., Maas, J., Mayer, D. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29804-5_17

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