Definition
Receptor serine/threonine kinases (RSKs) are transmembrane proteins of the plasma membrane and are characterized by extracellular ligand‐binding domains and cytoplasmic kinase domains. All RSKs of the human genome act as signaling receptors for members of the transforming growth factor β (TGF‐β) superfamily of secreted polypeptides (5). Accordingly, RSKs are known to play major roles in multiple physiological and pathological processes of metazoan life, including early embryogenesis, adult tissue homeostasis, atherosclerosis, tissue fibrosis and cancer (1, 3).
Characteristics
Type I and Type II RSKs
RSKs can be divided into two subgroups, the type I and type II RSKs, based on primary amino acid sequence comparison (5). Upon ligand binding, a heteromeric complex of type I and type II receptors are formed, in which the type II RSK phosphorylates and activates the type I RSK. Type I RSKs therefore play the major role in activating downstream effectors of the signaling pathway....
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© 2005 Springer-Verlag
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Moustakas, A., Souchelnytskyi, S., Heldin, C. (2005). Receptor Serine/Threonine Kinases. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_3130
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DOI: https://doi.org/10.1007/3-540-29623-9_3130
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
Online ISBN: 978-3-540-29623-2
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