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Directory of Microbicides for the Protection of Materials pp 9–25Cite as

Relationship between chemical structure and activity or mode of action of microbicides

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1 2.1 Introduction

Microbicides for preventing the biodeterioration of materials and thus preserve their value as long as possible have been developed formely more often empirically, however, today more often by design, because of greater knowledge and understanding of relationships between chemical structure and activity and mode of action of microbicides (Franklin and Snow, 1989).

Within groups of chemically related substances it is possible to correlate changes in biological activity with variations in chemical structure respectively in structural elements, or variations in chemical and physical properties. The chemical biology of the microbial cell is extremely complex, however. The chemist stands opposite large molecular systems and tries to solve the problem by assuming that only a small bounded part of a system has structure which interacts with structural (toxophoric) elements of microbicides. The resort to such abstraction allows to predict antimicrobial effectiveness of...

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Notes

  1. 1.

    *

    see Part Two — Microbicide data

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  1. W. Paulus
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Wilfried Paulus

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Paulus, W. (2004). Relationship between chemical structure and activity or mode of action of microbicides. In: Paulus, W. (eds) Directory of Microbicides for the Protection of Materials. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2818-0_2

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