2013, pp 3345-3366
Date: 15 May 2013

Quassinoids: Chemistry and Novel Detection Techniques

Abstract

Natural products play a dominant role in pharmaceutical industry, providing resources for the discovery of new drug molecules. Quassinoids are degraded triterpenes reported from the members of the Simarouboidaea subfamily of Simaroubaceae. The importance of quassinoids as antiplasmodial, anticancer and anti-HIV compounds has revived interest in them as potential drug candidates. Its efficacy as combinatorial drug coupled with the structure–activity analysis has reclaimed novel structural leads for new drug development. Quassinoids are categorized into five distinct groups according to their basic skeleton, viz., C-18, C-19, C-20, C-22, and C-25. This present entry reviews the structure, structure–activity relationship, and methods of isolation, detection, and characterization of quassinoids. Recent LC–MS/MS-based techniques could effectively provide more lead molecules which would act in synergism with other compounds.