Reference Work Entry

Natural Products

pp 3345-3366

Date:

Quassinoids: Chemistry and Novel Detection Techniques

  • Dipjyoti ChakrabortyAffiliated withDepartment of Bioscience and Biotechnology, Banasthali Vidyapith Email author 
  • , Amita PalAffiliated withDivision of Plant Biology, Bose Institute

Abstract

Natural products play a dominant role in pharmaceutical industry, providing resources for the discovery of new drug molecules. Quassinoids are degraded triterpenes reported from the members of the Simarouboidaea subfamily of Simaroubaceae. The importance of quassinoids as antiplasmodial, anticancer and anti-HIV compounds has revived interest in them as potential drug candidates. Its efficacy as combinatorial drug coupled with the structure–activity analysis has reclaimed novel structural leads for new drug development. Quassinoids are categorized into five distinct groups according to their basic skeleton, viz., C-18, C-19, C-20, C-22, and C-25. This present entry reviews the structure, structure–activity relationship, and methods of isolation, detection, and characterization of quassinoids. Recent LC–MS/MS-based techniques could effectively provide more lead molecules which would act in synergism with other compounds.

Keywords

Mass spectrometry quantitative structure–activity relationship Quassinoid