Myosin Work and Motility: Mechanism
- David AltmanAffiliated withDepartment of Physics, Willamette University Email author
Myosins are a superfamily of molecular motors that convert the chemical energy of ATP hydrolysis into directed motion along the filamentous protein actin.
Myosins function by converting the chemical energy associated with ATP hydrolysis into force and directed motion. The goal of this review is to discuss the coupled chemical and mechanical cycles that allow this energy transduction to occur and to examine how this kinetic cycle is “tuned” by the various myosin classes to achieve distinct functions.
Myosin Structural Features
Although there are at least 35 distinct myosin classes implicated in a variety of cellular processes (Ordonitz and Kollmar 2007), all myosins share certain structural features, which are discussed in detail in “Myosin: Fundamental Properties and Structure.” A brief overview is provided here.
Myosins exhibit a three-dom ...
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- Myosin Work and Motility: Mechanism
- Reference Work Title
- Encyclopedia of Biophysics
- pp 1671-1679
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- Springer Berlin Heidelberg
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- European Biophysical Societies' Association (EBSA)
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