Reference Work Entry

Encyclopedia of Cancer

pp 1523-1526

Gene Therapy

  • Valerie BoschAffiliated withUniversity Professor of Genetics, German Cancer Research Center - DKFZForschungsschwerpunkt Infektion und Krebs, F020, German Cancer Research Center (DKFZ) Email author 

Definition

Directed introduction and expression of new genetic information in cells of an organism for therapeutic purposes. Only somatic gene therapy is presently permitted, and the introduction of genetic material into germ-line cells is not allowed.

Characteristics

The science of gene therapy has its beginnings in the early 1980s, subsequent to the identification of several disease-related genes and the development of technologies for gene isolation, purification, and transfer to cells in culture. Many different human diseases represent theoretical targets for gene therapeutic intervention and the strategies developed depend on the nature of the disease to be treated. Table 1 illustrates several classes of human disease and the respective treatment strategies currently being followed. It goes without saying that detailed knowledge of the molecular mechanisms of disease development and progression is a prerequisite for the development of gene therapeutic interve ...

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