Reference Work Entry

Encyclopedia of Cancer

pp 1519-1519

Gelsolin Family


A superfamily of gelsolin-like proteins that has a conserved modular motif. Gelsolin is the founding member; other members include villin, scinderin, adseverin, supervillin, CapG, and flightless I. With the exception of flightless I, all are shown to be Ca2+-activated actin severing and/or binding proteins. Some of these proteins have also been implicated in transcriptional regulation.

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