Reference Work Entry

Encyclopedia of Cancer

pp 1371-1371

Date:

FAC

Definition

Focal adhesion complex is a multiprotein complex that is transiently formed inside the cell in response to ligand binding to integrins. FAC is attached to actin filaments that allow the cell to exert the mechanical tension required for cell movement. FAC can also activate other downstream signaling pathways that can alter cell migration.

Integrin Signaling

Osteopontin

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© Springer-Verlag Berlin Heidelberg 2011
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