Reference Work Entry

Encyclopedia of Psychopharmacology

pp 1110-1110

Quazepam

  • Britta HahnAffiliated withSection Behavioural Pharmacology, Institute of Psychiatry, King's College LondonMaryland Psychiatric Research Center, University of Maryland School of Medicine

Definition

Quazepam is a benzodiazepine with hypnotic and anticonvulsant properties. Clinically, quazepam is particularly effective in the short-term treatment of insomnia by inducing and maintaining sleep. Unlike other benzodiazepines, quazepam selectively targets GABAA type 1 receptors, but one of its major long-acting metabolites does not share this selectivity. Due to its long-lasting action, impairment of motor function is a significant side effect. Quazepam use is subject to tolerance, abuse, dependence, and withdrawal, although possibly with reduced severity as compared with other benzodiazepines.

Cross-References

Benzodiazepines

GABAA Receptors

Insomnias

Sedative, Hypnotic, and Anxiolytic Dependence

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