Addictive Disorder: Animal Models
- Michel Le Moal
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Experimental drug dependence
Animal model: Experimental preparation developed for studying a given phenomenon found in humans. It is at the basis of experimental medicine, with its two sides: physiology and pathology.
Individual differences: Refer to the concept of differential psychology, personality, and temperament. Each individual is unique in terms of genetic and environmental backgrounds, and of life events and history.
Vulnerability or frailty: A construct inherent to medical practice, for genetic or environmental reasons. It represents a biological state at the limits of homeostasis.
Current Concepts and State of Knowledge
Introduction: A Model of What?
In behavioral pathology and comparative psychiatry a precondition for an animal model is to be informed about what will be modeled. The poor awareness of the complexity of such human conditions is the origin of misunderstanding between clinicians and neurobiolo ...
- Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300 CrossRef
- American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, p 943
- Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305:1014–1017 CrossRef
- Geyer MA, Markou A (2002) The role of preclinical models in the development of psychotropic drugs. In: Davis KL, Charney D, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology: the fifth generation of progress. Lippincott Williams and Wilkins, New York, pp 445–455
- Katz JL, Higgins ST (2003) The validity of the reinstatement model of craving and relapse to drug use. Psychopharmacology 168:21–30 [erratum: 168:244] CrossRef
- Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52–58 CrossRef
- Koob GF, Le Moal M (2008) Addiction and the brain antireward system. Annu Rev Psychol 59:29–53 CrossRef
- McKinney WT (1988) Models of mental disorders: a new comparative psychiatry. Plenum, New York
- Piazza PV, Deminière JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513 CrossRef
- Vanderschuren LJ, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305:1017–1019 CrossRef
- Addictive Disorder: Animal Models
- Reference Work Title
- Encyclopedia of Psychopharmacology
- pp 20-28
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- Additional Links
- Industry Sectors
- eBook Packages
- Ian P. Stolerman (1)
- Editor Affiliations
- 1. Section Behavioural Pharmacology, Institute of Psychiatry, King's College London
- Michel Le Moal (1)
- Author Affiliations
- 1. Centre de Recherche Inserm u862, Université Victor Segalen-Bordeaux 2, Institut François Magendie-Bordeaux, 146 Rue Léo Saignat, 33077, Bordeaux, Cédex, France
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