Reference Work Entry

Encyclopedia of Psychopharmacology

pp 19-19

Acute Tolerance

  • Richard W. FoltinAffiliated withSection Behavioural Pharmacology, Institute of Psychiatry, King's College LondonCollege of Physicians and Surgeons of Columbia University, The New York State Psychiatric Institute

Definition

Acute tolerance is a diminution of effect either during a single drug-taking episode such that the drug produces greater effects as blood concentration increases compared to when blood concentration decreases, or if the effect is less on the second time that the drug is taken.

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