Bickerstaff's Brainstem Encephalitis
- Tomasz BerkowiczAffiliated withDepartment of Neurology, Medical University of Lodz
- , Krzysztof SelmajAffiliated withDepartment of Neurology, Medical University of Lodz
Bickerstaff's encephalitis; Bickerstaff's syndrome
Bickerstaff's brainstem encephalitis (BBE) is an uncommon central nervous system (CNS) disease characterized by acute external opthtalmoplegia, cerebellar ataxia with disturbances of consciousness and pyramidal signs. Its etiology remains unknown but it is postulated that BBE has an autoimmune origin because of an antecedent illness and frequently the presence of anti-GQ1b antibodies. BBE is usually a monophasic disease with a generally good outcome.
The first cases of descending brainstem syndrome were described in 1951 by Bickerstaff and Cloake under the title “Mesencephalitis and rhombencephalitis” . In 1957 Bickerstaff defined the disease as “brain-stem encephalitis” . The condition has been called Bickerstaff's brainstem encephalitis since 1978 when Bickerstaff wrote a review for the Handbook of Clinical Neurology under the title “Brain stem ...
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- Bickerstaff's Brainstem Encephalitis
- Reference Work Title
- Encyclopedia of Neuroscience
- pp 377-381
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag GmbH Berlin Heidelberg
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- Editor Affiliations
- 1. Department of Physiology & Biophysics, University of Washington School of Medicine
- 2. Department of Cell Biology and Anatomy, Graduate School of Medicine University of Tokyo Hongo
- Author Affiliations
- 1. Department of Neurology, Medical University of Lodz, Lodz, Poland
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