2009, pp 2862-2867

NF-κB – Potential Role in Adult Neural Stem Cells

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Synonyms

NF-κB: (NF-kappaB; NF-κB); DNA-binding subunits of NF- κB; p65 (RelA); p50 (NFKB1); p52 (NFKB2); c-Rel (REL); RelB (RELB); Inhibitory subunits of NF-κB: IκB-α (NFKBIA); IκB-β (NFKBIB); IκB-ε (NFKBIE); IκB-ζ (NFKBIZ)

Definition

Neural Stem Cells

Stem cells are defined as undifferentiated cells with the ability to (i) proliferate, (ii) exhibit self-maintenance, (iii) generate a large number of progeny, including the principal phenotypes of the tissue, (iv) retain their multilineage potential over time, and (v) generate new cells in response to injury or disease.

Neural stem cells can be found within their complex niche in the mammalian brain. Neural stem cells could be maintained in culture via propagation of floating cell clusters called “neurospheres.” Neurospheres contain committed progenitors, differentiated astrocytes, neurons and neural stem cells. A progenitor is defined as mitotic cell with a fast cell-devision cycle that retains the ability to proliferate ...