- Frank LammertAffiliated withDepartment of Internal Medicine I, University Hospital Bonn
- , Johann LorenzenAffiliated withInstitute of Pathology, Clinic of Dortmund gGmbH
Hepatic (epitheloid cell) granulomas
Definitions and Characteristics
Granulomatous hepatitis is a chronic exudative and proliferative inflammatory reaction of liver tissue that occurs in association with infections, systemic diseases or drugs and is characterized by nodular inflammatory infiltrates (granulomas) composed of macrophages, epitheloid cells, lymphocytes, and fibroblasts. A granuloma is a focal accumulation of epitheloid cells, which are transformed macrophages .
0.7–15% of all liver biopsies contain hepatic granulomas , but in many cases they are not accompanied by hepatitis, and no specific disease is detected during the course of further investigations.
There is substantial evidence from epidemiological and twin studies that host genetic factors are important in determining susceptibility to infections with Mycobacteria and the subsequent development of granulomas. Case-control (association) st ...
Reference Work Entry Metrics
- Hepatitis, Granulomatous
- Reference Work Title
- Encyclopedia of Molecular Mechanisms of Disease
- pp 818-821
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag GmbH Berlin Heidelberg
- Additional Links
- Industry Sectors
- eBook Packages
- Editor Affiliations
- 1. Institute of Physiology, University of Tuebingen
- Author Affiliations
- 1. Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
- 2. Institute of Pathology, Clinic of Dortmund gGmbH, Dortmund, Germany
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