Reference Work Entry

Encyclopedia of Molecular Mechanisms of Disease

pp 2056-2057

Thrombophlebitis

  • Henri BounameauxAffiliated withInstitute of Physiology, University of TuebingenAngiology and Hemostasis, University Hospitals of Geneva
  • , Marc RighiniAffiliated withInstitute of Physiology, University of TuebingenAngiology and Hemostasis, University Hospitals of Geneva

Synonyms

STP; DVT

Definition and Characteristics

STP is a usually benign thrombosis [1] of a superficial, varicose or nonvaricose vein characterized by local inflammatory signs (Fig. 1, left). Most of these events are located in the lower (the vast majority) or upper (most of them secondary to injections) extremities. In a minority of cases, STP may extend in the deep venous system and occasionally cause pulmonary embolism (PE).

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Thrombophlebitis. Figure 1

Clinical picture of superficial thrombophlebitis (left) and of iliofemoral deep vein thrombosis (right).

DVT is a thrombosis occurring in the deep vein system of the lower [2] (the vast majority) or upper (most of them secondary to central venous catheter or pacemaker) extremities. Other locations are exceptional. DVT of the lower extremities (Fig. 1, right) can be complicated by early (PE) or late (postthrombotic syndrome of the lower limbs or chronic pulmonary hypertension) complications.

Proximal DVT ...

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