- Andrea CavaniAffiliated withLaboratory of Immunology and Allergology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS
- , Giampiero GirolomoniAffiliated withDepartment of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona
Allergic contact dermatitis; Contact hypersensitivity
Definition and Characteristics
Itchy skin reaction with erythema, edema and vesicles occurring at the site of penetration of chemicals in pre-sensitized individuals. In the chronic phase, increased epidermal thickness with scales and painful fissures are frequent.
Widely common disease in both professional and extraprofessional settings. Prevalence in general population varies dramatically depending on the source considered. It has been reported that 2–15% of individuals residing in industrialized countries are skin sensitized at least to one substance, but the general assumption is that prevalence is greatly underestimated.
Molecular and Systemic Pathophysiology
Contact allergy is the consequence of an unbalanced T cell immune reaction against small chemicals, named haptens, contacting the skin. In the sensitization process, the hapte ...
Reference Work Entry Metrics
- Contact Allergy
- Reference Work Title
- Encyclopedia of Molecular Mechanisms of Disease
- pp 412-413
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag GmbH Berlin Heidelberg
- Additional Links
- Industry Sectors
- Editor Affiliations
- 1. Institute of Physiology, University of Tuebingen
- Author Affiliations
- 1. Laboratory of Immunology and Allergology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
- 2. Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, Verona, Italy
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