Syphilis of the Central Nervous System
- Hilmar PrangeAffiliated withDepartment of Neurology, Georg-August-University Goettingen
Neurosyphilis; Neurolues; Tabetic, paretic, and meningovascular neurosyphilis; Syphilitic meningitis (primosecondary stage); Syphilis cerebrospinalis
Definition and Characteristics
Infection by Treponema pallidum (T.p.) induces syphilis – a multistage complaint with varying organ manifestations und courses. Syphilitic involvement of central nervous structures may occur in all stages after infection. Syphilitic meningitis in the primosecondary stage results in headache, nausea, vomiting, and stiff neck, at times combined with cranial nerve alterations (predominantly nerves II, VII, and VIII). Patients are usually afebrile. Laboratory indicators of inflammation such as increased sedimentation rate or C-reactive protein are mostly absent as are intrathecally synthesized antibodies against T.p.
CNS manifestations of tertiary syphilis are meningovascular neurosyphilis (syphilis cerebrospinalis), general paresis, and tabes dosalis. Meningovascular n ...
Reference Work Entry Metrics
- Syphilis of the Central Nervous System
- Reference Work Title
- Encyclopedia of Molecular Mechanisms of Disease
- pp 2011-2012
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- Springer Berlin Heidelberg
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- Springer-Verlag GmbH Berlin Heidelberg
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