- Wendy M. SealeyAffiliated withDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- , Donald M. MockAffiliated withDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
Vitamin H deficiency; Egg-white syndrome; Egg-white injury
Definition and Characteristics
A nutritional disorder that results due to a deficiency of the water-soluble, B vitamin biotin.
Overt biotin deficiency has never been reported in healthy individuals consuming a regular diet but has been demonstrated in three situations: prolonged intravenous feeding without biotin supplementation, prolonged consumption of raw egg white, and in one infant on a rice-based formula without biotin . Biotin deficiency also occurs in patients with three hereditary disorders: biotinidase deficiency, holocarboxylase synthetase deficiency, and biotin transporter deficiency [2,3]. Other conditions that predispose patients to marginal degrees of biotin deficiency include anticonvulsant medications, liver disease, inflammatory bowel disease and pregnancy.
Biotin deficiency can result from mutations in holocarboxylase synthetase or in ...
Reference Work Entry Metrics
- Biotin Deficiency
- Reference Work Title
- Encyclopedia of Molecular Mechanisms of Disease
- pp 223-224
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag GmbH Berlin Heidelberg
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