- Johannes BayerAffiliated withDepartment of Dermatology, University Hospital of Muenster
- , Stefan BeissertAffiliated withDepartment of Dermatology, University Hospital of Muenster
Definition and Characteristics
Vitiligo is an acquired, idiopathic hypomelanotic disorder in which a progressive loss of melanocytes from the epidermis and hair follicles results in well-circumscribed cutaneous depigmented macules .
Vitiligo is the most common pigmentary disorder worldwide. The prevalence is 0.5–2% without a predilection for age, sex or race.
Several candidate genes have been proposed for vitiligo susceptibility, including genes important for melanin biosynthesis, response to oxidative stress and/or regulation of autoimmunity [2,3]. However, none of these vitiligo susceptibility genes has yet been identified. Case-control studies examining human leukocyte antigens (HLA) have shown a positive association with HLA DR4 and a negative association with HLA DR3 .
Molecular and Systemic Pathophysiology
The mechanisms leading to the loss of pigment cells are not yet fully underst ...
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- Reference Work Title
- Encyclopedia of Molecular Mechanisms of Disease
- pp 2227-2228
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- Springer Berlin Heidelberg
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- Springer-Verlag GmbH Berlin Heidelberg
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