- Marsha A. Moses Ph.D.
- … show all 1 hide
The angiogenic switch refers to a key early stage in solid tumor progression during which an avascular tumor lesion first becomes vascularized (Fig. 1) (Harper and Moses 2006). The acquisition of this angiogenic phenotype is a rate-limiting step in a tumor’s development in that these new capillaries provide necessary nutrients and gas exchange for the nascent tumor. The acquisition of a capillary network is required for exponential growth of the tumor and for its metastasis. It has been proposed that the angiogenic switch occurs as a function of a perturbation in the balance between angiogenic stimulators and inhibitors in favor of the positive regulators (Folkman 2002; Harper and Moses 2006).
- Angiogenic Switch
- Reference Work Title
- Encyclopedia of Systems Biology
- pp 28-29
- Print ISBN
- Online ISBN
- Springer New York
- Copyright Holder
- Springer Science+Business Media, LLC
- Additional Links
- eBook Packages
- Editor Affiliations
- 1. Biomedical Sciences Research Institute, University of Ulster
- 2. Department of Computer Science, University of Rostock
- 3. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- 4. Department of Biomedical Engineering, Rensselaer Polytechnic Institute
- Marsha A. Moses Ph.D. (15481)
- Author Affiliations
- 15481. Department of Surgery/Harvard Medical School, Vascular Biology Program/Children’s Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA
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