ChIP-on-Chip Assay

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Definition

ChIP-on-CHIP Assay is a method to determine the location of the genomic DNA to which a DNA-binding protein binds. The protein is cross-linked to DNA, usually in vivo, and the DNA is fragmented. The DNA fragments cross-linked with the protein are then immunoprecipitated, and hybridized to DNA chip or directly sequenced to determine the location.

Cross-References

Transcription in Bacteria