Minimum Detectable Amount

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n (MDA) In chemical analysis, the least amount of a substance being sought that balances two risks, Type I, the risk of falsely finding the substance to be present when in fact it is not, and Type II, the risk of not detecting that least amount. Typically, the two risks are made equal and, if both are 5%, the MDA is very nearly four times the standard deviation of the method. Lowering the risk increases MDA.