Reference Work Entry

Blaustein’s Pathology of the Female Genital Tract

pp 193-252

Precancerous Lesions of the Cervix

  • Thomas C. WrightAffiliated withDepartment of Pathology, Columbia Presbyterian Medical Center Email author 
  • , Brigitte M. RonnettAffiliated withDepartment of Pathology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine
  • , Robert J. KurmanAffiliated withDepartments of Gynecology, Obstetrics, Pathology and Oncology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine
  • , Alex FerenczyAffiliated withJewish General Hospital, McGill University

Abstract

The histopathological classification of a disease should reflect both current concepts of its pathogenesis as well as its clinical behavior. Over the last 50 years, our understanding of the pathobiology and behavior of cervical cancer precursors has evolved considerably. As a result, the terminology used to classify preinvasive lesions of the cervix has frequently changed. Although these changes in nomenclature and the resulting lack of a uniform terminology have been an ongoing source of confusion to both gynecologists and pathologists, each change has actually reduced the number of specific pathological categories and has made clinical decision making more straightforward.