FGR (Gene Name)
c-FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene
FGR is a cytoplasmic protein-tyrosine kinase belonging to the SRC family of protein tyrosine kinases. This kinase was originally described in the context of a feline sarcoma virus isolated from a spontaneous sarcoma of a domestic house cat and named GR-FeSV (Gardner-Rasheed feline sarcoma virus), whose primary translation product was shown to be a 70 kDa gag-fgr fusion peptide (Rasheed et al. 1982). Later studies identified this peptide as having a portion with amino acid homology with actin and another one related to a tyrosine kinase homologous to gene sequences present in the DNA of diverse invertebrate species (Naharro et al. 1984; Naharro et al. 1983). FGR is expressed in human and murine hematopoietic cells including granulocytes, monocytes/macrophages, natural killer cells, platelets, and erythrocytes (Berton 2006; Lowell 2004). Its function has been mainly chara ...
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- FGR (Gene Name)
- Reference Work Title
- Encyclopedia of Signaling Molecules
- pp 609-612
- Print ISBN
- Online ISBN
- Springer New York
- Copyright Holder
- Springer Science+Business Media, LLC
- Additional Links
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- Sangdun Choi (1)
- Editor Affiliations
- 1. Department of Molecular Science and Technology, Ajou University
- Author Affiliations
- 01641. Department of Pathology and Diagnostics, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
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