FGR (Gene Name)

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c-FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene

Historical Background

FGR is a cytoplasmic protein-tyrosine kinase belonging to the SRC family of protein tyrosine kinases. This kinase was originally described in the context of a feline sarcoma virus isolated from a spontaneous sarcoma of a domestic house cat and named GR-FeSV (Gardner-Rasheed feline sarcoma virus), whose primary translation product was shown to be a 70 kDa gag-fgr fusion peptide (Rasheed et al. 1982). Later studies identified this peptide as having a portion with amino acid homology with actin and another one related to a tyrosine kinase homologous to gene sequences present in the DNA of diverse invertebrate species (Naharro et al. 1984; Naharro et al. 1983). FGR is expressed in human and murine hematopoietic cells including granulocytes, monocytes/macrophages, natural killer cells, platelets, and erythrocytes (Berton 2006; Lowell 2004). Its function has been mainly chara ...