Reference Work Entry

Encyclopedia of Genetics, Genomics, Proteomics and Informatics

pp 935-935

Hydrogen Bond

A weak bond between one electronegative atom and a hydrogen atom that is covalently linked to another electronegative atom C or N. Hydrogen bonds tie together the polynucleotide chains of a DNA double helix (A = T and G ≡ C), and also affect conformation of proteins. hydrogen pairing, base analogs, Watson and Crick model, protein structure; Pauling L 1960 The Nature of the Chemical Bond, Cornell Univ. Press, Ithaca, NY; Luscombe NM et al 2001 Nucleic Acids Res 29:2860.

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