Centromere A Protein (CENP-A)

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A 17-kDa histone 3-like protein and part of the centromeric nucleosomes. Its disruption or loss severely affects mitosis and causes fragmentation of the chromatin. Its normal role is to mark centromere organization in the chromosome. centromere, centromere B protein, centromere C protein, CENP, histones; Murakami Y et al 1996 Proc Natl Acad Sci USA 93:502; Sugimoto K et al 2000 Cell Struct Funct 25:253.