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Includes gene neighborhoods where individual operons may show rearrangement in different species, yet remain in the functional and regulatory context (Lathe WC III et al 2000 Trends Biochem Sci 25:474). Rogozin and associates (Rogozin IB et al 2002 Nucleic Acids Res 30:2212) named this phenomenon genome hitchhiking. The largest such neighborhood in prokaryotes includes 79 genes. Most, albeit not all these genes, share a known functional role. operon, supraoperon