Preferential Segregation

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Non-random distribution of homologous chromosomes toward the pole during anaphase I of meiosis. There are four loci in the Abnormal 10 chromosome (carrying a terminal large knob) in maize that affect neocentromere activity, increased recombination, and preferential segregation (Hiatt EN, Dawe RK 2003 Genetics 164:699). If harmful combination of genes (gene blocks) is preferentially included in the gametes, this may constitute a genetic load. meiotic drive, neocentromere, polarized segregation; Rhoades MM, Dempsey E 1966 Genetics 53:989; Buckler ES et al 1999 Genetics 153:415.