Non-genic DNA

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About 0.3 to 1% of the human genome is highly conserved (CNG) across evolutionary boundaries, although these sequences are not transcribed or translated into protein. Their conservation is significantly higher than protein-coding genes or noncoding RNA genes. Although their functions are unknown, their profiles resemble that of protein-binding coding sequences. There are some indications that certain genetic anomalies are caused by alterations in these CNGs (Dermitzakis ET et al 2005 Nature Rev Genet 6:151). RNA noncoding; Dermitzakis E et al 2003 Science 302:1033.