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Adhesion molecule that is expressed on the surface of circulating leukocytes.
P-selectin belongs to the selectins, a family of vascular adhesion molecules. It is expressed mainly on platelets and endothelial cells and promotes rolling, adhesion and transmigration of leukocytes. P-selectin is a key molecule in leukocyte endothelial interactions especially modulating inflammatory pathways, wound healing and defense against infection. P-selectin acts as a signal transducer resulting in an increase of intracellular calcium and alteration of the cellular phenotype.
- Aplin AE, Howe A, Alahari SK, Juliano RL (1998) Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 50:197–263
- Lin E, Calvano SE, Lowry SF (1999) Selectin neutralization; does it make biological sense? Crit Care Med 27:2050–3
- Wagner DD (1995) P-selectin knockout: a mouse model for various human diseases. Ciba Found Symp 189:2–10
- Wang Q, Doerschuk CM (2002) The signaling pathways induced by neutrophil-endothelial cell adhesion. Antioxidants Redox Signaling 4:39–47
- Reference Work Title
- Rheumatology and Immunology Therapy
- pp 735-736
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- Springer Berlin Heidelberg
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- 2. University of Alabama at Birmingham
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