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Protein A immunoadsorption column.
The Prosorba column is the trade name for a staphylococcal protein A immunoadsorption column designed for use with plasmapheresis in the management of immune-mediated thrombocytopenia and rheumatoid arthritis.
In the clinic setting, patients undergo plasmapheresis with separation of plasma and cells. The plasma is then run over the Prosorba column, which uses staphylococcal protein to remove immunoglobulin and immune complexes. The plasma and cells are then re-mixed and infused. Prosorba columns have been approved for use in immune-mediated thrombocytopenia and rheumatoid arthritis. Randomized controlled trials show that over 40% of subjects with refractory RA met ACR criteria for improvement after 12 weekly treatments with Prosorba column in comparison to 15% response in patients undergoing sham pheresis. Unfortunately central venous access lines were associated with significant adverse events and a ...
- Furst, D, Felson, D, Thoren, G (2000) Immunoadsorption for the treatment of rheumatoid arthritis: final results of a randomized trial. Prosorba Trial Investigators. Ther Apheresis 4: pp. 363-73
- Sasso, EH, Merrill, C, Furst, TE (2001) Immunoglobulin binding properties of the Prosorba immunadsorption column in treatment of rheumatoid arthritis. Ther Apheresis 5: pp. 84-91
- Prosorba column
- Reference Work Title
- Rheumatology and Immunology Therapy
- pp 731-732
- Print ISBN
- Online ISBN
- Springer Berlin Heidelberg
- Copyright Holder
- Additional Links
- Industry Sectors
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- Editor Affiliations
- 2. University of Alabama at Birmingham
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