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An animal model for rheumatoid arthritis, considered by some to be a joint specific model without extra-articular cartilage involvement. Disease expression is considered MHC-associated and T-cell dependent. Thought to be an optimal animal model for RA as the disease progression fulfils the RA criteria and has a chronic relapsing disease course.
Anti-oncostatin M antibodies have been used to neutralize PIA in CBA mice, in which 65% of PIA/CBA controls developed arthritis while in anti-OSM AB treated animals 0% developed disease.
- Hansson AS, Lu S, Holmdahl R (2002) Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models. Clin Exp Immunol;127(1):37–42
- Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U (2001) Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev 184:184–202
- Plater-Zyberk C (2001) Amelioration of arthritis in two murine models using antibodies to oncostatin M. Arthritis Rheum 44(11):2697–702
- Pristane-induced arthritis
- Reference Work Title
- Rheumatology and Immunology Therapy
- p 729
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- Springer Berlin Heidelberg
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- 2. University of Alabama at Birmingham
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