Reference Work Entry

Rheumatology and Immunology Therapy

pp 729 -729

Pristane-induced arthritis

Definition

An animal model for rheumatoid arthritis, considered by some to be a joint specific model without extra-articular cartilage involvement. Disease expression is considered MHC-associated and T-cell dependent. Thought to be an optimal animal model for RA as the disease progression fulfils the RA criteria and has a chronic relapsing disease course.

Therapy

Pharmacological

Anti-oncostatin M antibodies have been used to neutralize PIA in CBA mice, in which 65% of PIA/CBA controls developed arthritis while in anti-OSM AB treated animals 0% developed disease.

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