Synonyms
Acute hemolytic transfusion reactions; Delayed transfusion reactions; Febrile non-hemolytic transfusion reactions; Transfusion associated circulatory overload; TACO; Transfusion related acute lung injury; TRALI
Definition and Characteristics
A transfusion reaction is an adverse event which occurs during or after the transfusion of a blood product [1,2]. In hemolytic transfusion reactions (HTRs), transfused donor red blood cells (RBCs) are destroyed by the host’s immune system and they can be acute (immediate) or delayed, and severe or mild. In severe acute hemolytic transfusion reactions (AHTRs), RBCs are destroyed intravascularly as seen with ABO-incompatible transfusion reactions and disseminated intravascular coagulation (DIC) and renal failure can also occur. In delayed transfusion reactions (DHTRs), RBCs are destroyed extravascularly, rarely causing hemoglobinemia and hemoglobinuria. Febrile non-hemolytic transfusion reactions (FNHTRs) are caused by antibodies in the...
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References
Beauregard P, Blajchman MA (1994) Hemolytic and pseudo-hemolytic transfusion reactions: an overview of the hemolytic transfusion reactions and the clinical conditions that mimic them. Transfus Med Rev 8:184–199
Toy P, Popovsky MA, Abraham E et al. (2005) Transfusion-related acute lung injury: definition and review. Crit Care Med 33:721–726
Sazama K (2003) Transfusion errors: scope of the problem, consequences, and solutions. Curr Hematol Rep 2:518–521
Davenport RD (2005) Pathophysiology of hemolytic transfusion reactions. Semin Hematol 42:165–168
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Yazdanbakhsh, K., Sutton, M. (2009). Transfusion Reactions. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_1767
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DOI: https://doi.org/10.1007/978-3-540-29676-8_1767
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
Online ISBN: 978-3-540-29676-8
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