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Snake Venoms

  • Living reference work
  • © 2020

Overview

Editors:
  1. P. Gopalakrishnakone

    1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  2. Hidetoshi Inagaki

    1. Biomedical Research Institute National Institute of Advanced Industria, Tsukuba, Japan

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  3. Ashis K. Mukherjee

    1. Department of Molecular Biology and Biot, Tezpur University, Tezpur, India

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  4. Tarek R. Rahmy

    1. Egyptian Society of Natural Toxins and Z, Faculty of Science Suez Canal University, Ismailia, Egypt

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  5. Carl-Wilhelm Vogel

    1. University of Hawaii Cancer Center, Honolulu, USA

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  • Complete and comprehensive overview of toxinology
  • Written by a very large team of experts from all around the world
  • Covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development

Part of the book series: Toxinology (TOXI)

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Table of contents (20 entries)

  1. A Brief Appraisal on Russell’s Viper Venom (Daboia russelii russelii) Proteinases

    • Rupamoni Thakur, Ashis K. Mukherjee

  2. Anticoagulant and Membrane Damaging Properties of Snake Venom Phospholipase A2 Enzymes

    • Debashree Saikia, Ashis K. Mukherjee

  3. Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management

    • J. P. Chippaux, R. P. Stock, A. Massougbodji

  4. Cellular Mechanisms of Action of Snake Phospholipase A2 Toxins

    • Fiorella Tonello, Michela Rigoni

  5. Cobra Venom Factor: The Unique Component of Cobra Venom That Activates the Complement System

    • Carl-Wilhelm Vogel, David C. Fritzinger

  6. Crotamine: Function Diversity and Potential Applications

    • M. P. Marinovic, C. Dal Mas, G. G. Monte, D. Felix, J. D. Campeiro, Mirian A. F. Hayashi

  7. Cytotoxic Effects of Snake Venoms

    • Dibakar Chakrabarty, Angshuman Sarkar

  8. Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom

    • Satohiko Araki

  9. Non-Cobra Venom Factor Venom Components Acting on Complement Proteins

    • Denise V. Tambourgi, Carmen W. van den Berg

  10. Phospholipase A2 Inhibitors from Snake Blood (sbPLIs)

    • Consuelo L. Fortes-Dias, Patrícia Cota Campos, Carlos Alexandre H. Fernandes, Marcos Roberto M. Fontes

  11. Role of Lymphatic System on Snake Venom Absorption

    • Dayanira Paniagua, Irene Vergara, Leslie Boyer, Alejandro Alagón

  12. Secreted Phospholipases A2 with β-Neurotoxic Activity

    • DuÅ¡an KordiÅ¡, Igor Križaj

  13. Snake Venom Components Affecting the Coagulation System

    • Miryam Paola Alvarez-Flores, Fernanda Faria, Sonia Aparecida de Andrade, Ana Marisa Chudzinski-Tavassi

  14. Snake Venom Disintegrins

    • Dibakar Chakrabarty, Chandrasekhar Chanda

  15. Snake Venom Protease Inhibitors: Enhanced Identification, Expanding Biological Function, and Promising Future

    • Hidetoshi Inagaki

  16. Snake Venom Toxins Targeted at the Nervous System

    • Alexey V. Osipov, Yuri N. Utkin

  17. Snake α-Neurotoxins and the Nicotinic Acetylcholine Receptor

    • Selvanayagam Nirthanan, Wasim Awal, Navin R. Niranjan

  18. Structural and Functional Diversity of Snake Sarafotoxins

    • Yazine Mahjoub, Stéphanie Malaquin, Frédéric Ducancel

  19. Toxinology of Snake Venoms: The Malaysian Context

    • Choo Hock Tan, Nget Hong Tan

  20. Vipericidins, Snake Venom Cathelicidin-Related Peptides, in the Milieu of Reptilian Antimicrobial Polypeptides

    • Gandhi Rádis-Baptista
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About this book

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Editors and Affiliations

  • Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    P. Gopalakrishnakone

  • Biomedical Research Institute National Institute of Advanced Industria, Tsukuba, Japan

    Hidetoshi Inagaki

  • Department of Molecular Biology and Biot, Tezpur University, Tezpur, India

    Ashis K. Mukherjee

  • Egyptian Society of Natural Toxins and Z, Faculty of Science Suez Canal University, Ismailia, Egypt

    Tarek R. Rahmy

  • University of Hawaii Cancer Center, Honolulu, USA

    Carl-Wilhelm Vogel

About the editors

Prof P. Gopalakrishnakone is a world leader in the characterization of the structure and function of animal and plant toxins and chemical poisons, which contain highly specific and biologically active components. He has contributed significantly to the body of knowledge regarding the anatomy of snake venom glands and the development of drug candidates from animal toxins. 

Prof Gopal pioneered the development of the NUS Venom and Toxin Research Programme, which has put NUS at the forefront of toxin research internationally.  The technology platform that has been built over the years under the Venom and Toxin Research Programme, coupled with its extensive library of protein and peptides, has enabled Prof Gopal and his team to complete the discovery process of lead candidates in time and to transfer valuable supplementary information to the next discovery steps involving profiling and optimization of lead candidates.  The objective is to characterize the venom components and natural toxins at a molecular level and identify promising compounds amenable to the development of novel human therapeutics.  Prof Gopal’s lab has identified over twenty peptides with unique medical indications from venom-based proteins with some already under development as therapeutics.

Prof Gopal’s research studies includes structure function studies (toxin detection, biosensors, antitoxins and neutralization factors), toxicogenomics and expression studies,  antimicrobial peptides from venoms and toxins and PLA2 inhibitors as potential drug candidate for inflammatory diseases.  The techniques he employs include quantum dots to toxinology, computational biology, microarrays and protein chips. He has patented analgesic peptide, anti inflammatory peptide as well as anti rheumatoid arthritis peptides. He is exploring various possibilities of delivery systems for these peptides to target sites and administration of these peptides orally, transdermally, ocular and injections.

Prof Gopal has over 100 international peer-reviewed papers in venom and toxin research, drug discovery, biosensors, and toxinogenomics. His research awards include the Outstanding University Researcher Award from the National University of Singapore (1998); Ministerial Citation, NSTB Year 2000 Award in Singapore; and the Research Excellence Award from the Faculty of Medicine, National University of Singapore (2003). His awards in teaching include, Faculty Teaching Excellence Award 2003/4 & NUS Annual Teaching Excellence Award 2003/4. He also received the Faculty Teaching Excellence Award in 2009/10 and the Annual Teaching Excellence Award, NUS FOR 2009/10. He is the President of International Society on Toxinology till 2012, and is a member of the editorial board of Toxicon, the official journal of the International Society on Toxinology.

 

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