2013

Drug Design

Methodology, Concepts, and Mode-of-Action

Editors:

ISBN: 978-3-642-17906-8 (Print) 978-3-642-17907-5 (Online)

Table of contents (32 entries)

previous Page of 2
  1. Front Matter

    Pages i-xv

  2. Part I Fundamentals in Drug Research

    1. Front Matter

      Pages 1-2

    2. No Access

      Reference Work Entry

      Pages 3-22

      Drug Research: Yesterday, Today, and Tomorrow

    3. No Access

      Reference Work Entry

      Pages 23-36

      In the Beginning, There Was Serendipity

    4. No Access

      Reference Work Entry

      Pages 37-60

      Classical Drug Research

    5. No Access

      Reference Work Entry

      Pages 61-88

      Protein–Ligand Interactions as the Basis for Drug Action

    6. No Access

      Reference Work Entry

      Pages 89-110

      Optical Activity and Biological Effect

  3. Part II The Search for the Lead Structure

    1. Front Matter

      Pages 111-112

    2. No Access

      Reference Work Entry

      Pages 113-128

      The Classical Search for Lead Structures

    3. No Access

      Reference Work Entry

      Pages 129-152

      Screening Technologies for Lead Structure Discovery

    4. No Access

      Reference Work Entry

      Pages 153-172

      Optimization of Lead Structures

    5. No Access

      Reference Work Entry

      Pages 173-188

      Designing Prodrugs

    6. No Access

      Reference Work Entry

      Pages 189-208

      Peptidomimetics

  4. Part III Experimental and Theoretical Methods

    1. Front Matter

      Pages 209-210

    2. No Access

      Reference Work Entry

      Pages 211-232

      Combinatorics: Chemistry with Big Numbers

    3. No Access

      Reference Work Entry

      Pages 233-264

      Gene Technology in Drug Research

    4. No Access

      Reference Work Entry

      Pages 265-290

      Experimental Methods of Structure Determination

    5. No Access

      Reference Work Entry

      Pages 291-314

      Three-Dimensional Structure of Biomolecules

    6. No Access

      Reference Work Entry

      Pages 315-334

      Molecular Modeling

    7. No Access

      Reference Work Entry

      Pages 335-346

      Conformational Analysis

  5. Part IV Structure–Activity Relationships and Design Approaches

    1. Front Matter

      Pages 347-348

    2. No Access

      Reference Work Entry

      Pages 349-370

      Pharmacophore Hypotheses and Molecular Comparisons

    3. No Access

      Reference Work Entry

      Pages 371-396

      Quantitative Structure–Activity Relationships

    4. No Access

      Reference Work Entry

      Pages 397-428

      From In Vitro to In Vivo: Optimization of ADME and Toxicology Properties

    5. No Access

      Reference Work Entry

      Pages 429-448

      Protein Modeling and Structure-Based Drug Design

previous Page of 2