2007

Handbook of Neurochemistry and Molecular Neurobiology

Brain Energetics. Integration of Molecular and Cellular Processes

ISBN: 978-0-387-30366-6 (Print) 978-0-387-30411-3 (Online)

Table of contents (33 entries)

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  1. Front Matter

    Pages i-xv

  2. Glucose Metabolism in Brain

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      Pages 3-16

      1.1 Bioenergetics

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      Pages 17-39

      1.2 Glucose, Oxidative Energy Metabolism, and Neural Function in Brain Slices—Glycolysis Plays a Key Role in Neural Activity

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      Pages 41-62

      1.3 Pentose Phosphate Pathway and NADPH Metabolism

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      Pages 63-91

      1.4 The Cerebral Tricarboxylic Acid Cycles

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      Pages 93-118

      1.5 Electron Transport. Structure, Redox-Coupled Protonmotive Activity, and Pathological Disorders of Respiratory Chain Complexes

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      Pages 119-134

      1.6 The Mitochondrial F1Fo ATP Synthase

  3. Alternative Substrates

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      Pages 137-179

      2.1 The Support of Energy Metabolism in the Central Nervous System with Substrates Other than Glucose

  4. Metabolic Specialization of Brain Cell Types and Compartmentation of Function

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      Pages 183-195

      3.1 Anaplerosis

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      Pages 197-238

      3.2 Glial–Neuronal Shuttle Systems

  5. Molecular and Cellular Architecture Link Energy Demand with Metabolite Fluxes

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      Pages 241-259

      4.1 Cytoplasmic Glycolytic Enzymes. Synaptic Vesicle-Associated Glycolytic ATP-Generating Enzymes: Coupling to Neurotransmitter Accumulation

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      Pages 261-295

      4.2 Mitochondrial Architecture and Heterogeneity

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      Pages 297-320

      4.3 Coupling of Neuronal Function to Oxygen and Glucose Metabolism Through Changes in Neurotransmitter Dynamics as Revealed with Aging, Hypoglycemia, and Hypoxia

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      Pages 321-342

      4.4 Coupling of Brain Function and Metabolism: Endogenous Flavoprotein Fluorescence Imaging of Neural Activities by Local Changes in Energy Metabolism

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      Pages 343-400

      4.5 Coupling of Brain Function to Metabolism: Evaluation of Energy Requirements

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      Pages 401-427

      4.6 Energy Consumption by Phospholipid Metabolism in Mammalian Brain

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      Pages 429-465

      4.7 Ion Transport and Energy Metabolism

  6. Regulation of Metabolic Fluxes and Metabolic Shuttling by Neural Environment

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      Pages 469-486

      5.1 Acid–Base Transport and pH Regulation

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      Pages 487-517

      5.2 Nitric Oxide in Regulation of Mitochondrial Function, Respiration, and Glycolysis

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      Pages 519-547

      5.3 Mitochondrial Production of Oxidants and Their Role in the Regulation of Cellular Processes

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      Pages 549-568

      5.4 Uncoupling Proteins

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