2006

Drug Discovery and Evaluation

Safety and Pharmacokinetic Assays

ISBN: 978-3-540-25638-0 (Print) 978-3-540-29804-5 (Online)

Table of contents (48 entries)

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  1. Safety Pharmacology

    1. Front Matter

      Pages 1-1

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      Pages 3-3

      Introduction to Safety Pharmacology

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      Pages 5-13

      Status of Safety Pharmacology and Present Guidelines

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      Pages 15-60

      Central Nervous System (CNS) Safety Pharmacology Studies

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      Pages 61-94

      Methods in Cardiovascular Safety Pharmacology

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      Pages 95-140

      Safety Pharmacology of Drugs for the Urinary Tract

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      Pages 141-149

      Respiratory Function Assays in Safety Pharmacology

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      Pages 151-193

      Metabolism Pharmacology

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      Pages 195-209

      Peripheral Nervous System

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      Pages 211-217

      Safety of Intravenous and Inhalation Anesthetics

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      Pages 219-231

      Side Effects of Central Analgesic Drugs

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      Pages 233-242

      Safety Pharmacology of Antiinflammatory Drugs

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      Pages 243-254

      Safety Pharmacology of Drugs with Osteoarthritis-Related Activity

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      Pages 255-318

      Safety Pharmacology of Blood Constituents

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      Pages 319-326

      Ocular Toxicity Tests

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      Pages 327-363

      Assays in Endocrine Safety Pharmacology

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      Pages 365-383

      Safety Assays in Skin Pharmacology

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      Pages 385-393

      Magnetic Resonance Imaging in Pharmaceutical Safety Assessment

  2. Safety Pharmacokinetics

    1. Front Matter

      Pages 395-295

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      Pages 397-398

      Introduction

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      Pages 399-408

      Physicochemical Properties

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      Pages 409-436

      In-Silico ADME Modeling

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