Abstract
Human factor VII (FVII) is a glycoprotein with a molecular mass of 50 kDa, is synthesized in the liver as a single-chain precursor of activated FVII (FVIIa), and it circulates in the blood at a plasma concentration of 0.5 μ/mL. FVIIa is a serine protease, generated by limited proteolysis of zymogen FVII by activated factors Xa (FXa) or IXa (FIXa) in vivo. Upon binding to its receptor, cofactor tissue factor (TF), FVIIa gains full catalytic activity and triggers the extrinsic blood coagulation pathway, activating its substrates, factors X (FX) and IX (FIX).
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Nakashima, T., Tomokiyo, K. (2005). Large-Scale Preparation of Factor VIIa from Human Plasma. In: Smales, C.M., James, D.C. (eds) Therapeutic Proteins. Methods in Molecular Biology™, vol 308. Humana Press. https://doi.org/10.1385/1-59259-922-2:177
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DOI: https://doi.org/10.1385/1-59259-922-2:177
Publisher Name: Humana Press
Print ISBN: 978-1-58829-390-9
Online ISBN: 978-1-59259-922-6
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