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Drug-DNA Interaction Protocols pp 1–22Cite as

DNase I Footprinting

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 90))

Abstract

Footprinting provides a simple, quick, and reasonably inexpensive method for assessing the sequence specific interaction of ligands with DNA. Although the technique was developed in 1978 for studying the interaction of DNA-binding proteins with then target sites (1), it has proved invaluable for determining the sequence specificity of many small ligands

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Authors and Affiliations

  1. Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, UK

    Keith R. Fox

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  1. Keith R. Fox
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  1. University of Southampton, UK

    Keith R. Fox

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© 1997 Humana Press Inc., Totowa NJ

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Fox, K.R. (1997). DNase I Footprinting. In: Fox, K.R. (eds) Drug-DNA Interaction Protocols. Methods in Molecular Biology™, vol 90. Humana Press, Totowa, NJ. https://doi.org/10.1385/0-89603-447-X:1

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  • DOI: https://doi.org/10.1385/0-89603-447-X:1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-447-1

  • Online ISBN: 978-1-59259-574-7

  • eBook Packages: Springer Protocols

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