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Target Discovery and Validation Reviews and Protocols

Volume 361 of the series Methods in Molecular Biology™ pp 63-91

Wnt Signaling as a Therapeutic Target for Cancer

  • Andreas HerbstAffiliated withClinical Research Unit for Gastrointestinal Cancers, Ludwig-Maximilians-UniversityDepartment of Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University
  • , Frank Thomas KolligsAffiliated withClinical Research Unit for Gastrointestinal Cancers, Ludwig-Maximilians-UniversityDepartment of Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University

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Abstract

The Wnt/β-catenin signaling pathway is tightly regulated and has important functions in development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin signaling is frequently found in various human cancers. Eighty percent of colorectal cancers alone reveal activation of this pathway by either inactivation of the tumor-suppressor gene adenomatous polyposis coli or mutation of the proto-oncogene β-catenin. Activation of Wnt/β-catenin signaling has been found to be important for both initiation and progression of cancers of different tissues. Therefore, targeted inhibition of Wnt/β-catenin signaling is a rational and promising new approach for the therapy of cancers of various origins.

Key Words

Wnt signalling adenomatous polyposis coli APC β-catenin Tcf LEF targeted therapy small molecules antisense siRNA RNAi