The Use of Conventional Immunologic Adjuvants in DNA Vaccine Preparations
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The term “adjuvant” originates from the Latin word adjuvare, which means to help or aid. An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens (1). In a broad sense, immunologic adjuvants include certain cytokines and other immunomodulatory molecules (i.e. chemokines and costimulatory factors) or their expression vectors. Since these adjuvants are described elsewhere in this book, here, we are concerned only with adjuvants that are derived from microorganisms and plants or are synthesized chemically.
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- Sasaki, S., Tsuji, T., Hamajima, K., Fukushima, J., Ishii, N., Kaneko, T., et al. (1997) Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against Human Immunodeficiency Virus Type 1. Infect. Immun. 65, 3520–3528.
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- Toda, S., Ishii, N., Okada, E., Kusakabe, K.-I., Arai, H., Hamajima, K., et al. (1997) HIV-1 specific cell-mediated immune responses induced by DNA vaccination are enhanced by mannan-coated liposomes and inhibited by anti-inter-feron (IFN)-gamma antibody. Immunology 92, 111–117. CrossRef
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- The Use of Conventional Immunologic Adjuvants in DNA Vaccine Preparations
- Book Title
- DNA Vaccines
- Book Subtitle
- Methods and Protocols
- pp 241-249
- Print ISBN
- Online ISBN
- Series Title
- Methods in Molecular Medicine™
- Series Volume
- Series ISSN
- Humana Press
- Copyright Holder
- Humana Press
- Additional Links
- Editor Affiliations
- 1. Mycobacterial Research Laboratory
- 2. Maxygen Inc.
- Author Affiliations
- 3. Division of Microbiology and Immunology, Yerkes Primate Research Center, Emory University, Atlanta, GA
- 4. Department of Bacteriology, Yokohama City University School of Medicine, Yokohama, Japan
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